The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8420072 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 16, 2013

Filed:

Mar. 24, 2011
Applicants:

Craig A. Shoemaker, Notasulga, AL (US);

Benjamin R. Lafentz, Auburn, AL (US);

Inventors:

Craig A. Shoemaker, Notasulga, AL (US);

Benjamin R. LaFentz, Auburn, AL (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 39/02 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

can cause infections in aquaculture-raised fish and is considered an opportunistic human pathogen. We isolatedfrom diseased hybrid tilapia (Oreochromis niloticus X O. aureus) cultured in a North American water reuse aquaculture facility. We have characterized the isolate using biochemical and molecular methods, developed a disease infection model, and determined that formalin-inactivated whole-cell vaccine provides protection against. Theisolate was determined to be biotype 1, 16S rRNA type B, vcg type C, and vvhA type 2. Fish vaccinated with the formalin-inactivated whole-cell vaccine responded to vaccination as measured by agglutinating antibody titer. In two separate trials, vaccinated tilapia exhibited relative percent survival of 73 and 60% following challenge with the homologous isolate. In additional trials, vaccinated tilapia exhibited survival values of up to 87.5% following challenge with a heterologous isolate. Use of a mineral oil adjuvant enhanced protection.


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