The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 16, 2013
Filed:
Jul. 24, 2009
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Wei Zhang, Los Angeles, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Kai Chen, Rockville, MD (US);
Anjana Sinha, San Diego, CA (US);
Eric Wang, San Diego, CA (US);
Gang Chen, Los Angeles, CA (US);
Peter J. H. Scott, Ypsilanti, MI (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Zhiyong Gao, Wynnewood, PA (US);
Tieming Zhao, Los Angeles, CA (US);
Chunfang Xia, Los Angeles, CA (US);
Vani P. Mocharla, Los Angeles, CA (US);
Hartmuth C. Kolb, Playa Del Rey, CA (US);
Joseph C. Walsh, Pacific Palisades, CA (US);
Wei Zhang, Los Angeles, CA (US);
Umesh B. Gangadharmath, Los Angeles, CA (US);
Dhanalakshmi Kasi, Los Angeles, CA (US);
Kai Chen, Rockville, MD (US);
Anjana Sinha, San Diego, CA (US);
Eric Wang, San Diego, CA (US);
Gang Chen, Los Angeles, CA (US);
Peter J. H. Scott, Ypsilanti, MI (US);
Henry Clifton Padgett, Hermosa Beach, CA (US);
Qianwa Liang, Hacienda Heights, CA (US);
Zhiyong Gao, Wynnewood, PA (US);
Tieming Zhao, Los Angeles, CA (US);
Chunfang Xia, Los Angeles, CA (US);
Vani P. Mocharla, Los Angeles, CA (US);
Siemens Medical Solutions USA, Inc., Malvern, PA (US);
Abstract
Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.