The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2013
Filed:
Apr. 30, 2012
Applicants:
Anastasia Khvorova, Northborough, MA (US);
Devin Leake, Denver, CO (US);
Barbara Robertson, Boulder, CO (US);
Annaleen Vermeulen, Lafayette, CO (US);
Christina Yamada, Boulder, CO (US);
Inventors:
Anastasia Khvorova, Northborough, MA (US);
Devin Leake, Denver, CO (US);
Barbara Robertson, Boulder, CO (US);
Annaleen Vermeulen, Lafayette, CO (US);
Christina Yamada, Boulder, CO (US);
Assignee:
Dharmacon, Inc., Lafayette, CO (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01);
U.S. Cl.
CPC ...
Abstract
Disclosed are methods of enhancing functionality of duplex oligonucleotides and compositions made by the methods. The duplex oligonucleotides include siRNAs, miRNA mimics, and piRNA mimics which contain modified nucleotides and mismatches between the two strands of the molecule at specific nucleotide positions.