The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2013
Filed:
Sep. 03, 2008
Zurit Levine, Herzliya, IL;
Tania Pergam, Rishon LeZion, IL;
Dalit Landesman-milo, Ramat Gan, IL;
Anat Cohen-dayag, Rehovot, IL;
Amir Toporik, Karkur, IL;
Yaron Kinar, Tel Aviv, IL;
Sergey Nemzer, Ranaana, IL;
Avi Rosenberg, Kfar Saba, IL;
Galit Rotman, Herzliya, IL;
Amit Novik, Tel Mond, IL;
Cynthia Koifman, Kfar Saba, IL;
Merav Beiman, Nes Ziona, IL;
Liat Dassa, Tel Aviv, IL;
Shira Walach, Hod Hasharon, IL;
Eve Montia, Rehovot, IL;
Shirley Sameach-greenwald, Kfar Saba, IL;
Ofer Levy, Jerusalem, IL;
Marina Bubis, Rehovot, IL;
Zurit Levine, Herzliya, IL;
Tania Pergam, Rishon LeZion, IL;
Dalit Landesman-Milo, Ramat Gan, IL;
Anat Cohen-Dayag, Rehovot, IL;
Amir Toporik, Karkur, IL;
Yaron Kinar, Tel Aviv, IL;
Sergey Nemzer, Ranaana, IL;
Avi Rosenberg, Kfar Saba, IL;
Galit Rotman, Herzliya, IL;
Amit Novik, Tel Mond, IL;
Cynthia Koifman, Kfar Saba, IL;
Merav Beiman, Nes Ziona, IL;
Liat Dassa, Tel Aviv, IL;
Shira Walach, Hod Hasharon, IL;
Eve Montia, Rehovot, IL;
Shirley Sameach-Greenwald, Kfar Saba, IL;
Ofer Levy, Jerusalem, IL;
Marina Bubis, Rehovot, IL;
Compugen Ltd, Tel Aviv, IL;
Abstract
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against VSIG1, ILDR1, LOC253012, AI216611, C1ORF32 or FXYD3 antigens, which are predicted co-stimulatory family members and which are differentially expressed in cancers including, lung cancer, ovarian cancer, and colon cancer, and diagnostic and therapeutic usages. The use of these antibodies for modulating B7 costimulation and related therapies such as the treatment of autoimmunity are also provided. This invention further relates to the discovery of extracellular domains of VSIG1 and its variants, FXYD3 and its variants, ILDR1 and its variants, LOC253012 and its variants, AI216611 and its variants, and C1ORF32 and its variants which are suitable targets for immunotherapy, cancer therapy, and drug development.