The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 09, 2013
Filed:
Jun. 13, 2011
Daniel E. Afar, Pacific Palisades, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Kahan Leong, Playa Del Rey, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas C. Saffran, Los Angeles, CA (US);
Stephen Chappell Mitchell, Santa Monica, CA (US);
Daniel E. Afar, Pacific Palisades, CA (US);
Rene S. Hubert, Los Angeles, CA (US);
Kahan Leong, Playa Del Rey, CA (US);
Arthur B. Raitano, Los Angeles, CA (US);
Douglas C. Saffran, Los Angeles, CA (US);
Stephen Chappell Mitchell, Santa Monica, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Described is a novel family of cell surface serpentine transmembrane antigens. Two of the proteins in this family are exclusively or predominantly expressed in the prostate, as well as in prostate cancer, and thus members of this family have been termed 'STEAP' (Six Transmembrane Epithelial Antigens of the Prostate). Four particular human STEAPs are described and characterized herein. The prototype member of the STEAP family, STEAP-1, appears to be a type IIIa membrane protein expressed predominantly in prostate cells in normal human tissues. Structurally, STEAP-1 is a 339 amino acid protein characterized by a molecular topology of six transmembrane domains and intracellular N- and C-termini, suggesting that it folds in a 'serpentine' manner into three extracellular and two intracellular loops. STEAP-1 protein expression is maintained at high levels across various stages of prostate cancer. Moreover, STEAP-1 is highly over-expressed in certain other human cancers.