The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2013
Filed:
Mar. 09, 2009
Shashiprabha, Bangalore, IN;
Kanakamajalu Shridhara, Bangalore, IN;
Debkiron Mukherjee, Bangalore, IN;
Padmashree Badraje, Bangalore, IN;
K Sundarraja Rao, Bangalore, IN;
Kuppuswamy Nagarajan, Bangalore, IN;
Shashiprabha, Bangalore, IN;
Kanakamajalu Shridhara, Bangalore, IN;
Debkiron Mukherjee, Bangalore, IN;
Padmashree Badraje, Bangalore, IN;
K Sundarraja Rao, Bangalore, IN;
Kuppuswamy Nagarajan, Bangalore, IN;
Alkem Laboratories Limited, Mumbai, IN;
Abstract
The present invention relates to a process for preparing Ziprasidone of formula I, or a pharmaceutically acceptable salt or a solvate or a hydrate thereof;comprising the steps of reacting 1-(1,2-benzisothiazol-3-yl) piperazine of formula II or its salt: with 5-(2-haloethyl)-6-chloro-oxindole of formula III: wherein X is leaving groups like fluoro, chloro, bromo, iodo or sulphonyl;in the presence of a dispersing agent and a base in a solvent to form ziprasidone of formula I; and optionally converting the ziprasidone formed into a pharmaceutically acceptable acid addition salts of ziprasidone; or a solvate or a hydrate thereof.