The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2013
Filed:
Mar. 14, 2012
Brian J. Carroll, Gig Harbor, WA (US);
Gary Darland, Gig Harbor, WA (US);
Anuradha Desai, Gig Harbor, WA (US);
Veera Konda, Gig Harbor, WA (US);
Clinton J. Dahlberg, Port Orchard, WA (US);
Jan Urban, Gig Harbor, WA (US);
Brian J. Carroll, Gig Harbor, WA (US);
Gary Darland, Gig Harbor, WA (US);
Anuradha Desai, Gig Harbor, WA (US);
Veera Konda, Gig Harbor, WA (US);
Clinton J. Dahlberg, Port Orchard, WA (US);
Jan Urban, Gig Harbor, WA (US);
KinDex Therapeutics, LLC, Seattle, WA (US);
Abstract
The present application provides cis 3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one derivatives and substantially enantiomerically pure compositions thereof. These derivatives include (+)-(4S,5R)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, (−)-(4R,5S)-3,4-dihydroxy-2-(3-methylbutanoyl)-5-(3-methylbutyl)-4-(4-methylpentanoyl)cyclopent-2-en-1-one, and salts and crystals thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, activate GPR120, inhibit inflammation, and treat conditions responsive to PPARγ modulation, conditions responsive to GPR120 modulation, and metabolic disturbances such as diabetes.