The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8410098 B1

PDF
Full Text
Expired
Date of Patent:
Apr. 02, 2013

Filed:

Dec. 28, 2007
Applicants:

Guanghui Tian, Shanghai, CN;

Zheng Liu, Shanghai, CN;

Jin Zheng, Shanghai, CN;

Jingshan Shen, Shanghai, CN;

Inventors:

Guanghui Tian, Shanghai, CN;

Zheng Liu, Shanghai, CN;

Jin Zheng, Shanghai, CN;

Jingshan Shen, Shanghai, CN;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 253/065 (2006.01); C07D 253/00 (2006.01); C07D 487/04 (2006.01); A61K 31/53 (2006.01); A61P 15/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III and utilized for preparing vardenafil), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure


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