The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2013
Filed:
Jun. 05, 2002
Kevin Williams, Chapel Hill, NC (US);
Paul Rayhorn, Foxborough, MA (US);
Ellen A. Garber, Cambridge, MA (US);
R. Blake Pepinsky, Arlington, MA (US);
Kevin Williams, Chapel Hill, NC (US);
Paul Rayhorn, Foxborough, MA (US);
Ellen A. Garber, Cambridge, MA (US);
R. Blake Pepinsky, Arlington, MA (US);
Curis. Inc., Lexington, MA (US);
Abstract
Variants of hedgehog protein that contain N-terminal modifications are described that can block hedgehog function; thus allowing these variants to serve as functional antagonists. These peptides have a primary amino acid sequence lacking the ability to elicit a hedgehog-dependent response in C3H 10T1/2 cells but having the ability to bind to the hedgehog receptor, patched-1. Methods for producing such functional antagonists and methods of using the functional antagonists are also described.