The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2013
Filed:
Oct. 20, 2010
James B. Delehanty, Washington, DC (US);
Igor L. Medintz, Springfield, VA (US);
Hedi M. Mattoussi, Tallahassee, FL (US);
Jeffrey R. Deschamps, Laurel, MD (US);
Glyn Dawson, Chicago, IL (US);
Philip E. Dawson, San Diego, CA (US);
Juan Bautista Blanco-canosa, A Coruna, ES;
Kelly Boeneman, Arlington, VA (US);
James B. Delehanty, Washington, DC (US);
Igor L. Medintz, Springfield, VA (US);
Hedi M. Mattoussi, Tallahassee, FL (US);
Jeffrey R. Deschamps, Laurel, MD (US);
Glyn Dawson, Chicago, IL (US);
Philip E. Dawson, San Diego, CA (US);
Juan Bautista Blanco-Canosa, A Coruna, ES;
Kelly Boeneman, Arlington, VA (US);
The United States of America, as represented by the Secretary of the Navy, Washington, DC (US);
The University of Chicago, Chicago, IL (US);
Abstract
Described are peptides for delivery of a nanoparticle to the cytosol, the peptide comprising: (a) a nanoparticle association domain; (b) a proline-rich spacer domain; (c) an uptake domain; and (d) a vesicle escape domain comprising a non-hydrolyzable lipid moiety, wherein the spacer domain is between the nanoparticle association domain and the uptake and vesicle escape domains, and wherein the peptide, when attached to an extracellular nanoparticle, is effective to induce uptake of the nanoparticle by a cell and delivery of the nanoparticle to the cytosol of the cell. Also described are methods of delivery of a nanoparticle to the cytosol of a cell, the method comprising providing to a cell a nanoparticle attached to such a peptide. Exemplary nanoparticles include quantum dots.