The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 02, 2013
Filed:
Jul. 17, 2008
Daniel J. Schneider, Arvada, CO (US);
Sheri K. Wilcox, Longmont, CO (US);
Dominic Zichi, Boulder, CO (US);
Dan Nieuwlandt, Longmont, CO (US);
Jeff Carter, Longmont, CO (US);
Larry Gold, Boulder, CO (US);
Daniel J. Schneider, Arvada, CO (US);
Sheri K. Wilcox, Longmont, CO (US);
Dominic Zichi, Boulder, CO (US);
Dan Nieuwlandt, Longmont, CO (US);
Jeff Carter, Longmont, CO (US);
Larry Gold, Boulder, CO (US);
Somalogic, Inc., Boulder, CO (US);
Abstract
The present disclosure describes improved SELEX methods for generating nucleic acid ligands that are capable of binding to target molecules and improved photoSELEX methods for generating photoreactive nucleic acid ligands that are capable of both binding and covalently crosslinking to target molecules. The disclosure further describes nucleic acid libraries having expanded physical and chemical properties and their use in SELEX and photoSELEX; methods for increasing the crosslinking efficiencies of photoaptamers; methods for producing photoaptamers having selective modifications that enhance functionality and minimize non-specific photoreactions; and methods for generating truncated nucleic acid ligands from nucleic acid ligands of longer length. The disclosure further describes aptamers and photoaptamers obtained by using any of the foregoing.