The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2013
Filed:
Nov. 01, 2007
George T. Gillies, Charlottesville, VA (US);
Helen Fillmore, Richmond, VA (US);
William C. Broaddus, Midlothian, VA (US);
Boyd M. Evans, Iii, Oak Ridge, TN (US);
Stephen W. Allison, Knoxville, TN (US);
George T. Gillies, Charlottesville, VA (US);
Helen Fillmore, Richmond, VA (US);
William C. Broaddus, Midlothian, VA (US);
Boyd M. Evans, III, Oak Ridge, TN (US);
Stephen W. Allison, Knoxville, TN (US);
UT-Battelle, LLC, Oak Ridge, TN (US);
University of Virginia Patent Foundation, Charlottesville, VA (US);
Abstract
A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.