The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 26, 2013
Filed:
May. 16, 2008
Susan K. Keay, Ellicott City, MD (US);
David Zacharias, Palm Coast, FL (US);
Sonia L. Planey, St. Augustine, FL (US);
Susan K. Keay, Ellicott City, MD (US);
David Zacharias, Palm Coast, FL (US);
Sonia L. Planey, St. Augustine, FL (US);
University of Florida Research Foundation, Inc., Gainesville, FL (US);
University of Maryland, Baltimore, MD (US);
The United States of America as represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
The invention generally concerns inhibition of a molecule that has a role in post-translational modification of a receptor for antiproliferative factor (APF) of bladder epithelial cells, thereby modulating the APF. In particular, inhibition of DHHC2 activity and/or ZDHHC2 expression results in modulation of APF receptor activity, and in specific aspects such modulation is therapeutic and/or preventative for a bladder condition, such as interstitial cystitis. In addition, inhibition of CKAP4 palmitoylation in certain cases also decreases its activity as a tPA receptor on smooth muscle cells or surfactant A on type II pneumocytes, and/or generally inhibits its function as a cell membrane receptor, cell chaperone molecule, and/or membrane trafficking agent.