The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Sep. 02, 2011
Hong Liang, San Francisco, CA (US);
Yasmina Noubia Abdiche, Mountain View, CA (US);
Javier Fernando Chaparro Riggers, San Mateo, CA (US);
Bruce Charles Gomes, Ashburnham, MA (US);
Julie Jia LI Hawkins, Old Lyme, CT (US);
Jaume Pons, San Bruno, CA (US);
Yuli Wang, San Diego, CA (US);
Hong Liang, San Francisco, CA (US);
Yasmina Noubia Abdiche, Mountain View, CA (US);
Javier Fernando Chaparro Riggers, San Mateo, CA (US);
Bruce Charles Gomes, Ashburnham, MA (US);
Julie Jia Li Hawkins, Old Lyme, CT (US);
Jaume Pons, San Bruno, CA (US);
Yuli Wang, San Diego, CA (US);
Rinat Neuroscience Corp., South San Francisco, CA (US);
Pfizer Inc., New York, NY (US);
Abstract
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.