The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Dec. 28, 2009
Tomoaki Nakagawa, Tokyo, JP;
Sayaka Hori, Tokyo, JP;
Rinpei Niwa, Tokyo, JP;
Tsuguo Kubota, Tokyo, JP;
Kazuhiro Masuda, Tokyo, JP;
Kazuyasu Nakamura, Tokyo, JP;
Tomoaki Nakagawa, Tokyo, JP;
Sayaka Hori, Tokyo, JP;
Rinpei Niwa, Tokyo, JP;
Tsuguo Kubota, Tokyo, JP;
Kazuhiro Masuda, Tokyo, JP;
Kazuyasu Nakamura, Tokyo, JP;
Kyowa Hakko Kirin Co., Ltd, Tokyo, JP;
Abstract
An anti-CD4 antibody which binds to CD4, has a high affinity and has a high effector activity, such as an antibody-dependent cellular cytotoxicity (ADCC activity) or complement-dependent cellular cytotoxicity (CDC activity), is required for a disease relating to a CD4-expressing cell. The present invention can provide a monoclonal antibody or an antibody fragment thereof, which binds to a CD4 extracellular region with high affinity and also exhibits a high ADCC activity or a high CDC activity; a hybridoma which produces the antibody; a DNA which encodes the antibody; a vector which contains the DNA; a transformant obtainable by introducing the vector; a process for producing an antibody or an antibody fragment thereof using the hybridoma or the transformant; and a therapeutic agent using the antibody or the antibody fragment thereof or a diagnostic agent using the antibody or the antibody fragment thereof.