The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
May. 25, 2007
Aryl-or heteroaryl-substituted pyrido[2,3-d] pyrimidines and pharmaceutical compositions of the same
Santiago Figueroa Perez, Leverkusen, DE;
Peter Kolkhof, Wuppertal, DE;
Lars Bärfacker, Oberhausen, DE;
Ingo Flamme, Reichshof, DE;
Karl-heinz Schlemmer, Wuppertal, DE;
Alexander Kuhl, Hagen, DE;
Rolf Grosser, Leverkusen, DE;
Klaus Münter, Mülfrath, DE;
Andreas Knorr, Erkrath, DE;
Santiago Figueroa Perez, Leverkusen, DE;
Peter Kolkhof, Wuppertal, DE;
Lars Bärfacker, Oberhausen, DE;
Ingo Flamme, Reichshof, DE;
Karl-Heinz Schlemmer, Wuppertal, DE;
Alexander Kuhl, Hagen, DE;
Rolf Grosser, Leverkusen, DE;
Klaus Münter, Mülfrath, DE;
Andreas Knorr, Erkrath, DE;
Bayer Intellectual Property GmbH, Monheim, DE;
Abstract
The present application relates to novel aryl- or heteroaryl-substitued pyrido[2,3-d] pyrimidines of formula (I), pharmaceuitical compositions of the same, and a process for their preparation. Formula(I) is: wherein Ar is an aryl or heteroaryl substituent, and R, R, R, Ar, D, and E are as defined in the specification. Compounds and compositions of the present invention can be used in the treatment and/or prophylaxis of various disorders in humans and animals, including aldosteronism, high blood pressure, chronic heart failure, the sequelae of a myocardial infarction, cirrhosis of the liver, renal failure, and stroke.