The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Apr. 05, 2007
Patrick Neuberg, Illkirch, FR;
Anne-laure Bolcato Bellemin, Strasbourg, FR;
Jean-paul Behr, Strasbourg, FR;
Patrick Erbacher, Benfeld, FR;
Patrick Neuberg, Illkirch, FR;
Anne-Laure Bolcato Bellemin, Strasbourg, FR;
Jean-Paul Behr, Strasbourg, FR;
Patrick Erbacher, Benfeld, FR;
Polyplus-Transfection, Illkirch Cedex, FR;
Abstract
The invention relates to compositions of transfection comprising an oligonucleotide and an amphiphilic cationic molecule of formula (I) wherein, —X is N—R, S or O, Rbeing a C1-C4 alkyl radical or an hydroxylated C3-C6 alkyl radical, Rand R, identical or different, represent H or a C1-C4 alkyl radical, or Rand Rare linked together to form a saturated or unsaturated cycle or a heterocycle having 5 or 6 elements, E is a C1-C5 alkyl spacer, Rand R, identical or different, represent saturated or unsaturated, linear or branched, C10-C36 hydrocarbon or fluorocarbon chains, optionally comprising C3-C6 cycloalkyl, A− is a biocompatible anion. The invention relates to compositions active for oligonucleotides delivery into eukaryotic cells in culture, ex vivo or in vivo. The invention relates to compositions of transfection comprising an oligonucleotide active for RNA interference. Such compositions can be used as tools for biological studies or as drugs for therapies.