The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Feb. 01, 2006
Carlijin V. C. Bouten, Eindhoven, NL;
Anita Mol, Eindhoven, NL;
Marcel C. M. Rutten, Eindhoven, NL;
Simon P. Hoerstrup, Zurich, CH;
Frank P. T. Baaijens, Eindhoven, NL;
Carlijin V. C. Bouten, Eindhoven, NL;
Anita Mol, Eindhoven, NL;
Marcel C. M. Rutten, Eindhoven, NL;
Simon P. Hoerstrup, Zurich, CH;
Frank P. T. Baaijens, Eindhoven, NL;
Universitaet Zuerich, Zurich, CH;
Technische Universiteit Eindhoven, Eindhoven, NL;
Abstract
Developing heart valves are exposed to dynamic strains by applying a dynamic pressure difference over the leaflets. The flow is kept to a minimum, serving only as a perfusion system, supplying the developing tissue with fresh nutrients. Standard heart valves were engineered based on B trileaflet scaffolds seeded with cells isolated from the human saphenous vein. Tissue compaction is constrained by the stent, inducing increasing pre-strain in the tissue. The dynamic strains the tissues are exposed to via the dynamic pressure difference, are estimated using finite element methods based on the mechanical properties of the neo-tissue, in order to get inside into the strain distribution over the leaflet.