The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Jul. 18, 2006
Oskar Zelder, Speyer, DE;
Stefan Haefner, Speyer, DE;
Andrea Herold, Ketsch, DE;
Corinna Klopprogge, Mannheim, DE;
Hartwig Schroder, Nussloch, DE;
R. Rogers Yocum, Lexington, MA (US);
Mark K. Williams, Revere, MA (US);
Oskar Zelder, Speyer, DE;
Stefan Haefner, Speyer, DE;
Andrea Herold, Ketsch, DE;
Corinna Klopprogge, Mannheim, DE;
Hartwig Schroder, Nussloch, DE;
R. Rogers Yocum, Lexington, MA (US);
Mark K. Williams, Revere, MA (US);
Evonik Degussa GmbH, Essen, DE;
Abstract
The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants ofor, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain ofcan use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.