The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Oct. 22, 2010
Wendy J. Fantl, San Francisco, CA (US);
David B. Rosen, Mountain View, CA (US);
Alessandra Cesano, Redwood City, CA (US);
Santosh K. Putta, Foster City, CA (US);
James R. Hackett, San Jose, CA (US);
Michael Walker, Mountain View, CA (US);
Jing Shi, Mountain View, CA (US);
Wendy J. Fantl, San Francisco, CA (US);
David B. Rosen, Mountain View, CA (US);
Alessandra Cesano, Redwood City, CA (US);
Santosh K. Putta, Foster City, CA (US);
James R. Hackett, San Jose, CA (US);
Michael Walker, Mountain View, CA (US);
Jing Shi, Mountain View, CA (US);
Nodality, Inc., South San Francisco, CA (US);
Abstract
The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN.