The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 19, 2013
Filed:
Oct. 15, 2010
Chengbin Wu, Shanghai, CN;
Chung-ming Hsieh, Newtown, MA (US);
Renee Miller, N. Grosvenordale, CT (US);
Dominic J. Ambrosi, Shrewsbury, MA (US);
Chengbin Wu, Shanghai, CN;
Chung-ming Hsieh, Newtown, MA (US);
Renee Miller, N. Grosvenordale, CT (US);
Dominic J. Ambrosi, Shrewsbury, MA (US);
AbbVie Inc., North Chicago, IL (US);
Abstract
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.