The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Sep. 28, 2010
Paul S. Nelson, Morgan Hill, CA (US);
Hugh Mackie, Round Hill, VA (US);
Andrew Murphy, Brookeville, MD (US);
Paul S. Nelson, Morgan Hill, CA (US);
Hugh Mackie, Round Hill, VA (US);
Andrew Murphy, Brookeville, MD (US);
Glen Research Corporation, Sterling, VA (US);
Nelson Biotechnologies, Inc., Morgan Hill, CA (US);
Abstract
Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5' or 3′ termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.