Indoles and their therapeutic use

Abstract

Compound of formula (I) are ligands of the CRTH2 receptor, useful inter alia for treatment of inflammatory conditions. Wherein X is —SO— or *—SONR— wherein the bond marked with an asterisk is attached to Ar; Ris hydrogen, fluoro, chloro, CN or CF; Ris hydrogen, fluoro or chloro; Ris hydrogen, CCalkyl or C-Ccycloalkyl; Aris phenyl or a 5- or 6-membered heteroaryl group selected from furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C-Ccycloalkyl, —O(C-Calkyl) or CCalkyl, the latter two groups being optionally substituted by one or more fluoro atoms; and Aris phenyl or 5- or 6-membered heteroaryl group selected from pyrrolyl, furanyl, thienyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, pyridinyl, pyridazinyl, pyrimidinyl and pyrazinyl, wherein the phenyl or heteroaryl groups are optionally substituted by one or more substituents independently selected from fluoro, chloro, CN, C-C-Ccycloalkyl, —O(C-Calkyl) or CCalkyl, the latter two groups being optionally substituted by one or more fluoro atoms.