The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 12, 2013

Filed:

Apr. 18, 2008
Applicants:

Herbert H. Samuels, New Rochelle, NY (US);

Ruben Abagyan, La Jolla, CA (US);

Matthieu Schapira, Toronto, CA;

Maxim Totrov, San Diego, CA (US);

Bruce M. Raaka, Rockville, MD (US);

Stephen R. Wilson, Danville, VA (US);

LI Fan, Cambridge, MA (US);

Zhiguo Zhou, Winston Salem, NC (US);

Inventors:

Herbert H. Samuels, New Rochelle, NY (US);

Ruben Abagyan, La Jolla, CA (US);

Matthieu Schapira, Toronto, CA;

Maxim Totrov, San Diego, CA (US);

Bruce M. Raaka, Rockville, MD (US);

Stephen R. Wilson, Danville, VA (US);

Li Fan, Cambridge, MA (US);

Zhiguo Zhou, Winston Salem, NC (US);

Assignees:

Molsoft LLC, La Jolla, CA (US);

New York University School of Medicine, New York, NY (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/438 (2006.01); A61K 31/4418 (2006.01); A61P 5/16 (2006.01); C07D 211/70 (2006.01); C07D 471/10 (2006.01);
U.S. Cl.
CPC ...
Abstract

A method of identification of compounds that modulate thyroid hormone activity, and the use of such compounds and compositions thereof for such purposes are disclosed. The compounds may be selected from the group consisting of: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of conditions that are causally related to aberrant thyroid hormone activity, such as hyperthyroidism and thyrotoxicosis.


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