The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Mar. 22, 2012
Georgette Castanedo, Redwood City, CA (US);
Bryan Chan, San Carlos, CA (US);
David Goldstein, Nutley, NJ (US);
Rama Kondru, Nutley, NJ (US);
Matthew Lucas, Nutley, NJ (US);
Wylie Palmer, Nutley, NJ (US);
Stephen Price, Harlow, GB;
Brian Safina, Redwood City, CA (US);
Pascal Pierre Alexandre Savy, Harlow, GB;
Eileen Mary Seward, Harlow, GB;
Daniel P. Sutherlin, Burlingame, CA (US);
Zachary K. Sweeney, Redwood City, CA (US);
Georgette Castanedo, Redwood City, CA (US);
Bryan Chan, San Carlos, CA (US);
David Goldstein, Nutley, NJ (US);
Rama Kondru, Nutley, NJ (US);
Matthew Lucas, Nutley, NJ (US);
Wylie Palmer, Nutley, NJ (US);
Stephen Price, Harlow, GB;
Brian Safina, Redwood City, CA (US);
Pascal Pierre Alexandre Savy, Harlow, GB;
Eileen Mary Seward, Harlow, GB;
Daniel P. Sutherlin, Burlingame, CA (US);
Zachary K. Sweeney, Redwood City, CA (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
Formula I (Ia and Ib) compounds wherein (i) Xis N and Xis S, (ii) Xis CRand Xis S, (iii) Xis N and Xis NR, or (iv) Xis CRand Xis O, including stereoisomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.