The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 12, 2013
Filed:
Nov. 04, 2009
Salman Ali, Hoffman Estates, IL (US);
Ryan M. Bonn, Kenosha, WI (US);
Frank C. Grenier, Libertyville, IL (US);
Tracey D. Rae, Glenview, IL (US);
Kevin R. Rupprecht, Gurnee, IL (US);
Hina N. Syed, Gurnee, IL (US);
Bailin Tu, Libertyville, IL (US);
Joan D. Tyner, Beach Park, IL (US);
Ryan F. Workman, Gurnee, IL (US);
Salman Ali, Hoffman Estates, IL (US);
Ryan M. Bonn, Kenosha, WI (US);
Frank C. Grenier, Libertyville, IL (US);
Tracey D. Rae, Glenview, IL (US);
Kevin R. Rupprecht, Gurnee, IL (US);
Hina N. Syed, Gurnee, IL (US);
Bailin Tu, Libertyville, IL (US);
Joan D. Tyner, Beach Park, IL (US);
Ryan F. Workman, Gurnee, IL (US);
Abbott Laboratories, Abbott Park, IL (US);
Abstract
A composition comprising neutrophil gelatinase-associated lipocalin (NGAL), which has been enriched from urine, has a molecular weight of about 24.9 kDa to about 25.9 kDa, and comprises a plurality of isoforms having isoelectric points (pIs) ranging from about 5.9 to about 9.1; a composition comprising NGAL, which has been enriched from recombinant Chinese hamster ovary (CHO) cells, has a molecular weight of about 25.9 kDa to about 27.9 kDa, and comprises a plurality of isoforms having pIs ranging from about 5.6 to about 9.1; a method of obtaining from urine a composition comprising a plurality of isoforms of NGAL, which method comprises enriching NGAL in urine without separating molecules based on charge; a method of obtaining from recombinant CHO cells a composition comprising a plurality of isoforms of NGAL, which method comprises enriching NGAL in a composition without separating molecules based on charge; and a method of analyzing NGAL isoforms enriched from urine or recombinant CHO cells comprising analyzing an enriched composition comprising NGAL isoforms by two-dimensional electrophoresis and Western blot.