The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 12, 2013

Filed:

Jan. 10, 2011
Applicants:

Kenzo Bamba, Ibaraki, JP;

Yasuyuki Kuroiwa, Ibaraki, JP;

Tomohiro Morio, Tokyo, JP;

Norio Shimizu, Yamanashi, JP;

Inventors:

Kenzo Bamba, Ibaraki, JP;

Yasuyuki Kuroiwa, Ibaraki, JP;

Tomohiro Morio, Tokyo, JP;

Norio Shimizu, Yamanashi, JP;

Assignee:

Lymphotec Inc., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/08 (2006.01); C12N 5/00 (2006.01); A61K 38/21 (2006.01); C07K 1/00 (2006.01); A01N 63/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

HLA matched activated lymphocytes in mononuclear cells separated from peripheral blood or umbilical cord blood are proliferated and activated. After separating and collecting, the HLA matched activated lymphocytes are employed as the main component of a composition for promoting survival of transplanted hematopoietic stem cells. The obtained composition is widely usable in, for instance, prevention of survival failure of transplanted hematopoietic stem cells and therapy for promoting the survival thereof. Although the dose of the composition varies depending on the age, conditions, etc. of a patient, a humanized antibody is administered in a dose of from 0.2 to 20 ml/kg/day to mammals including humans. The composition is administered by intravenous injection either once a day (single administration or continuous administration) or intermittently once to 3 times in a week or once in 2 or 3 weeks.


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