The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Apr. 19, 2010
Applicants:
Ryu Hirata, Chiyoda-ku, JP;
Tatsuya Matsukawa, Chiyoda-ku, JP;
Kazuhiro Masuzaki, Chiyoda-ku, JP;
Ryuji Ueno, Potomac, MD (US);
Inventors:
Ryu Hirata, Chiyoda-ku, JP;
Tatsuya Matsukawa, Chiyoda-ku, JP;
Kazuhiro Masuzaki, Chiyoda-ku, JP;
Ryuji Ueno, Potomac, MD (US);
Assignees:
Sucampo AG, Zug, CH;
R-Tech Ueno, Ltd., Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 307/85 (2006.01); C07C 57/26 (2006.01); C07C 69/608 (2006.01);
U.S. Cl.
CPC ...
Abstract
Disclosed is a method for preparing a prostaglandin derivative of formula (A): which comprises reacting an aldehyde represented by formula (1): with a 2-oxoalkyl phosphonate in a reaction solvent under the presence of alkali hydroxide as sole base. By carrying out the reaction using an alkali hydroxide as sole base in the reaction system, the desired prostaglandin derivative can be obtained by simple procedures and with high yield.