The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Jan. 30, 2009
Siro Serafini, Alte di Montecchio Maggiore, IT;
Filippo Tomasi, Alte di Montecchio Maggiore, IT;
Marco Galvagni, Alte di Montecchio Maggiore, IT;
Siro Serafini, Alte di Montecchio Maggiore, IT;
Filippo Tomasi, Alte di Montecchio Maggiore, IT;
Marco Galvagni, Alte di Montecchio Maggiore, IT;
F.I.S. Fabbrica Italiana Sintetici S.p.A., Alte diMontecchio Maggiore, IT;
Abstract
The present invention relates to a process for the synthesis of quetiapine. In particular, a process is provided for the synthesis of quetiapine of formula (A) comprising reacting dibenzo[b,f][1,4]thiazepin-11(10H)-one, intermediate (I) with phosphorous oxychloride to give 11-chlorodibenzo[b,f][1,4]thiazepine, intermediate (II) wherein the said reaction of intermediate (I) to intermediate (II) is performed in an organic solvent in the presence of a mixture of an organic base together with an inorganic base.