The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Feb. 13, 2009
Menci Kunstelj, Skofja Loka, SI;
Gabriela Ambrozic, Ljubljana, SI;
Vladka Gaberc Porekar, Ljubljana, SI;
Veronika Verbic, Logatec, SI;
Menci Kunstelj, Skofja Loka, SI;
Viktor Menart, Logatec, SI;
Gabriela Ambrozic, Ljubljana, SI;
Vladka Gaberc Porekar, Ljubljana, SI;
Lek Pharmaceuticals D.D., Ljubljana, SI;
Abstract
The invention relates to a modifying agent comprising a water soluble polymer, wherein the water soluble polymer comprises at least one reactive selenium group, said reactive selenium group being capable of reacting with a thiol group thereby forming an —Se—S— bond. Furthermore, the invention relates to a method for producing said modifying agents and their use in the modification of pharmaceutically active agents, e.g. G-CSF. Additionally, the invention concerns conjugates comprising a water-soluble polymer and a pharmaceutically active agent, wherein the water-soluble polymer is linked via a S—Se-bond to agent and a method for their production and their use as medicaments. Finally, the invention concerns a pharmaceutical composition comprising the inventive conjugates.