The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 05, 2013

Filed:

Apr. 06, 2009
Applicants:

Richard V. Connors, Pacifica, CA (US);

Kang Dai, Albany, CA (US);

John Eksterowicz, San Francisco, CA (US);

Pingchen Fan, Fremont, CA (US);

Benjamin Fisher, San Mateo, CA (US);

Jiasheng Fu, Foster City, CA (US);

Kexue LI, Mountain View, CA (US);

Zhihong LI, Millbrae, CA (US);

Lawrence R. Mcgee, Pacifica, CA (US);

Rajiv Sharma, Mumbai, IN;

Xiaodong Wang, Millbrae, CA (US);

Inventors:

Richard V. Connors, Pacifica, CA (US);

Kang Dai, Albany, CA (US);

John Eksterowicz, San Francisco, CA (US);

Pingchen Fan, Fremont, CA (US);

Benjamin Fisher, San Mateo, CA (US);

Jiasheng Fu, Foster City, CA (US);

Kexue Li, Mountain View, CA (US);

Zhihong Li, Millbrae, CA (US);

Lawrence R. McGee, Pacifica, CA (US);

Rajiv Sharma, Mumbai, IN;

Xiaodong Wang, Millbrae, CA (US);

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/54 (2006.01); A61K 31/505 (2006.01); C07D 237/00 (2006.01); C07D 239/00 (2006.01); C07D 241/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.


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