The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Jul. 21, 2008
Guido Galley, Rheinfelden, DE;
Annick Goergler, Colmar, FR;
Katrin Groebke Zbinden, Liestal, CH;
Roger Norcross, Olsberg, CH;
Henri Stalder, Basel, CH;
Guido Galley, Rheinfelden, DE;
Annick Goergler, Colmar, FR;
Katrin Groebke Zbinden, Liestal, CH;
Roger Norcross, Olsberg, CH;
Henri Stalder, Basel, CH;
Hoffmann-La Roche Inc., Nutley, NJ (US);
Abstract
The present invention relates to compounds of formula I whereinR, R, R, Ar, n and o are as defined herein and to their pharmaceutically acceptable active salts. Compounds of formula I have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1 and are useful for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.