The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
May. 13, 2011
Marijeta Kralj, Zagreb, HR;
Kata Majerski, Zagreb, HR;
Tatjana Sumanovac Ramljak, Zagreb, HR;
Marko Marjanovic, Zagreb, HR;
Marijeta Kralj, Zagreb, HR;
Kata Majerski, Zagreb, HR;
Tatjana Sumanovac Ramljak, Zagreb, HR;
Marko Marjanovic, Zagreb, HR;
Rudjer Boskovic Institute, , HR;
Abstract
The invention relates to adamantane diaza-crown ether derivatives and the use of mono and diaza-crown ether adamantine derivatives in treatment, especially in tumor treatment. Adamantane aza-crown ethers were obtained by reaction of the corresponding adamantane derived tosylates or adamantane acid chlorides with mono- and diaza-18-crown-6. The prepared compounds showed moderate (monoaza-18-crown-6) to strong (diaza-18-crown-6) antiproliferative and cytotoxic activity on several tumor cell lines, revealing their potential for inhibiting the growth of other tumor cells.