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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8389500 B1

PDFFull Text
Date of Patent:
Mar. 05, 2013

Filed:

Oct. 28, 2009

Fused heterocyclic compounds as ion channel modulators

Applicants:

Matthew Abelman, Mountain View, CA (US);

Elfatih Elzein, Fremont, CA (US);

Robert Jiang, Milpitas, CA (US);

Rao Kalla, Sunnyvale, CA (US);

Tetsuya Kobayashi, Sunnyvale, CA (US);

Xiaofen LI, Mountain View, CA (US);

Thao Perry, San Jose, CA (US);

Jeff Zablocki, Los Altos, CA (US);

Inventors:

Matthew Abelman, Mountain View, CA (US);

Elfatih Elzein, Fremont, CA (US);

Robert Jiang, Milpitas, CA (US);

Rao Kalla, Sunnyvale, CA (US);

Tetsuya Kobayashi, Sunnyvale, CA (US);

Xiaofen Li, Mountain View, CA (US);

Thao Perry, San Jose, CA (US);

Jeff Zablocki, Los Altos, CA (US);

Assignee:

Gilead Sciences, Inc., Foster City, CA (US);

Attorneys:

Francis O. Ginah

J. Ellin Hartrum

Primary Examiner:

Fiona T Powers

Int. Cl.
CPC ...
A61K 31/18 (2006.01); A61K 31/196 (2006.01); A61K 31/24 (2006.01); A61K 31/41 (2006.01); A61K 31/44 (2006.01); A61K 31/445 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 31/662 (2006.01); A61P 3/10 (2006.01); A61P 9/00 (2006.01); A61P 25/02 (2006.01); A61P 25/08 (2006.01); C07C 311/08 (2006.01); C07C 311/14 (2006.01); C07D 213/42 (2006.01); C07D 213/82 (2006.01); C07D 257/04 (2006.01); C07D 295/13 (2006.01); C07F 9/40 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula (IA) or (IB): as further described herein. The invention also relates to methods for the preparation of the compounds, and to pharmaceutical compositions containing such compounds.

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