The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Oct. 31, 2007
Cornelis Maria Jacobus Sagt, Utrect, NL;
Cornelis Theodorus Verrips, Houten, NL;
Walraven Henry Muller, Dordrecht, NL;
Noël Nicolaas Maria Elisabeth Van Peij, Delfgauw, NL;
Cornelis Maria Jacobus Sagt, Utrect, NL;
Cornelis Theodorus Verrips, Houten, NL;
Walraven Henry Muller, Dordrecht, NL;
Noël Nicolaas Maria Elisabeth Van Peij, Delfgauw, NL;
DSM IP Assets B.V., Heerlen, NL;
Abstract
The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.