The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 05, 2013
Filed:
Feb. 27, 2009
Marcos Lopez, Wauwatosa, WI (US);
Micael Joel Hardy, La Seyne sur mer, FR;
Balaraman Kalyanaraman, Wauwatosa, WI (US);
Ming Zhao, Brookfield, WI (US);
Marcos Lopez, Wauwatosa, WI (US);
Micael Joel Hardy, La Seyne sur mer, FR;
Balaraman Kalyanaraman, Wauwatosa, WI (US);
Ming Zhao, Brookfield, WI (US);
Other;
Abstract
Tc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging.Tc-Mito-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared toTc-MIBI.Tc-Mito-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.