The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 26, 2013
Filed:
Oct. 12, 2010
Martyn Frederickson, Cambridge, GB;
Marian Williams, Cambridge, GB;
Brian John Williams, Cambridge, GB;
Martyn Frederickson, Cambridge, GB;
Astex Therapeutics Limited, Cambridge, GB;
Abstract
The invention provides a compound of the formula (1): or a salt, solvate, N-oxide or tautomer thereof;wherein either Ris Rand Ris R; or Ris Rand Ris R; provided that in each case at least one of Rand Ris other than hydrogen;Rand Rare the same or different and each is selected from hydrogen, Calkyl, Calkenyl and Calkynyl wherein the Calkyl is optionally substituted by Calkoxy;Rand Rare the same or different and are selected from hydrogen, C(O)NRR, C(O)Rand C(O)ORwhere Ris Calkyl, Rand Rare both Calkyl, or NRRforms a 4 to 7 membered saturated heterocyclic ring optionally containing a second heteroatom ring member selected from O, N or S and oxidized forms of N and S, the heterocyclic ring being optionally substituted by one or two Calkyl groups and/or one or two oxo groups; andRis a group D: wherein the asterisk denotes the point of attachment to the isoindoline ring;but excluding acetic acid 5-acetoxy-4-isopropyl-2-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindole-2-carbonyl]-phenyl ester.