The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Apr. 06, 2009
Jacopo Zanon, Venice, IT;
Giovanna Libralon, Galliera Veneta, IT;
Andrea Nicole′, Ponte S. Nicolo′, IT;
Jacopo Zanon, Venice, IT;
Giovanna Libralon, Galliera Veneta, IT;
Andrea Nicole′, Ponte S. Nicolo′, IT;
Lundbeck Pharmaceuticals Italy S.p.A., Padua, IT;
Abstract
A method is described for preparing argatroban monohydrate obtained from (2R,4R)-1-[N-nitro-N-(3-methyl-8-quinolinesulphonyl)-L-arginyl]-4-methyl-2-piperidine carboxylic acid by suitably treating crude argatroban. The method either comprises preparation of argatroban monohydrate in a continuous step or an intermediate step of isolating a purified argatroban. Also obtainable from argatroban monohydrate is anhydrous argatroban, shown to have new physico-chemical characteristics. The described argatroban synthesis and purification process hence enables three different forms of argatroban, not previously described, to be obtained, each with distinctive physico-chemical characteristics and in particular enables argatroban monohydrate to be obtained with high yield and with high purity, being therefore a product suitable for use as active principle in proprietary medicines.