The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Oct. 24, 2008
Barry Thomas King, Boulder, CO (US);
Paul Adam Bury, Thornton, CO (US);
Richard A. Gabel, Louisville, CO (US);
John Edward Crider, Boulder, CO (US);
Robert Thad Carr, Ii, Effingham, SC (US);
Bradley S. Dehoff, Longmont, CO (US);
Barry Thomas King, Boulder, CO (US);
Paul Adam Bury, Thornton, CO (US);
Richard A. Gabel, Louisville, CO (US);
John Edward Crider, Boulder, CO (US);
Robert Thad Carr, II, Effingham, SC (US);
Bradley S. DeHoff, Longmont, CO (US);
Corden Pharma Colorado, Inc., Boulder, CO (US);
Abstract
The present invention relates to the preparation of insulinotropic peptides that are synthesized using a solid and solution phase ('hybrid') approach. Generally, the approach includes synthesizing three different peptide intermediate fragments using solid phase chemistry. Solution phase chemistry is then used to add additional amino acid material to one of the fragments. The fragments are then coupled together in the solution phase. The use of a pseudoproline in one of the fragments eases solid phase synthesis of that fragment and also eases subsequent solution phase coupling of this fragment to other fragments. The present invention is very useful for forming insulinotropic peptides such as Exenatide(1-39) and its natural and non-natural counterparts.