The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Feb. 24, 2011
Abraham Nudelman, Rechovot, IL;
Ada Rephaeli, Herzlia, IL;
Irit Gil-ad, Herzlia, IL;
Abraham Weizman, Tel-Aviv, IL;
Mazal Shaul, Azur, IL;
Efrat Halbfinger, RaAnana, IL;
Abraham Nudelman, Rechovot, IL;
Ada Rephaeli, Herzlia, IL;
Irit Gil-Ad, Herzlia, IL;
Abraham Weizman, Tel-Aviv, IL;
Mazal Shaul, Azur, IL;
Efrat Halbfinger, RaAnana, IL;
Ramot at Tel-Aviv University Ltd., Tel-Aviv, IL;
Bar-Ilan University, Ramat-Gan, IL;
BioLineRX Ltd., Jerusalem, IL;
Abstract
Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.