The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Jul. 02, 2009
Seiji Yoshimura, Tokyo, JP;
Noriyuki Kawano, Tokyo, JP;
Tomoaki Kawano, Tokyo, JP;
Daisuke Sasuga, Tokyo, JP;
Takanori Koike, Tokyo, JP;
Hideyuki Watanabe, Tokyo, JP;
Hiroki Fukudome, Tokyo, JP;
Nobuyuki Shiraishi, Tokyo, JP;
Ryosuke Munakata, Tokyo, JP;
Hiroaki Hoshii, Tokyo, JP;
Kayoko Mihara, Tokyo, JP;
Seiji Yoshimura, Tokyo, JP;
Noriyuki Kawano, Tokyo, JP;
Tomoaki Kawano, Tokyo, JP;
Daisuke Sasuga, Tokyo, JP;
Takanori Koike, Tokyo, JP;
Hideyuki Watanabe, Tokyo, JP;
Hiroki Fukudome, Tokyo, JP;
Nobuyuki Shiraishi, Tokyo, JP;
Ryosuke Munakata, Tokyo, JP;
Hiroaki Hoshii, Tokyo, JP;
Kayoko Mihara, Tokyo, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
[Problem] A compound, which can be used for preventing or treating diseases, in which 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is concerned, in particular, diabetes, insulin resistance, dementia, schizophrenia and depression, is provided. [Means for Solution] It was found that a triazole derivative, in which one of the 3- and 5-positions of the triazole ring has (di)alkylmethyl or cycloalkyl, each of which is substituted with —O— (aryl or a heterocyclic group, each of which may be substituted, or lower alkylene-cycloalkyl), and the other thereof has aryl, a heterocyclic group or cycloalkyl, each of which may be substituted, or a pharmaceutically acceptable salt thereof exhibits potent 11β-HSD1 inhibitory action. From the above, the triazole derivative of the present invention can be used for preventing or treating diabetes, insulin resistance, dementia, schizophrenia and depression.