The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Nov. 21, 2002
Maurizio Fraziano, Rome, IT;
Sanjay Kumar Garg, Chhatishgarh, IN;
Antonio Ciaramella, Genazzano, IT;
Giovanni Auricchio, Ciampino, IT;
Elisabetta Volpe, Rome, IT;
Angelo Martino, Monterotondo Scalo, IT;
Patrizia Morena Baldihi, Rome, IT;
Paolo DE Vito, S. Marinella, IT;
Domenico Galati, Rome, IT;
Vittorio Colizzi, Rome, IT;
Maurizio Fraziano, Rome, IT;
Sanjay Kumar Garg, Chhatishgarh, IN;
Antonio Ciaramella, Genazzano, IT;
Giovanni Auricchio, Ciampino, IT;
Elisabetta Volpe, Rome, IT;
Angelo Martino, Monterotondo Scalo, IT;
Patrizia Morena Baldihi, Rome, IT;
Paolo De Vito, S. Marinella, IT;
Domenico Galati, Rome, IT;
Vittorio Colizzi, Rome, IT;
Universita Degli Studi di Roma “Tor Vergata”, Rome, IT;
Abstract
The invention relates to sphingosine derivative compounds, like D-erythro-sphingosine 1-phosphate (S1P), to be used as immunomodulators in a microbicidal treatment of infections derived from bacteria and specifically. Such compounds are characterized in that they stimulate macrophagic Phospholipase D (PLD) (FIG.). The invention further relates to pharmaceutical compositions containing sphingosine derivative compounds and diagnostic methods for the preparation thereof. Further objects of the invention are methods of inducing or restoring the microbicidal activity in vitro of macrophages for monitoring the efficiency of phagocytosis and degradation processes performed by the same and assay methods suitable to evaluate therapeutic effectiveness of candidate microbicides.