The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Nov. 21, 2008
Daniel J. Wendt, Walnut Creek, CA (US);
Mika Aoyagi-scharber, Mill Valley, CA (US);
Sean Bell, San Rafael, CA (US);
Dong Wei, San Francisco, CA (US);
Joshua R. Bliesath, Escondido, CA (US);
Emil D. Kakkis, Novato, CA (US);
Daniel J. Wendt, Walnut Creek, CA (US);
Mika Aoyagi-Scharber, Mill Valley, CA (US);
Sean Bell, San Rafael, CA (US);
Dong Wei, San Francisco, CA (US);
Joshua R. Bliesath, Escondido, CA (US);
Emil D. Kakkis, Novato, CA (US);
Biomarin Pharmaceutical Inc., Novato, CA (US);
Abstract
The present invention provides variants of C-type natriuretic peptide (CNP) comprising one or more deletions; additions of and/or substitutions with natural amino acids, unnatural amino acids and/or peptidomimetics (including peptide bond isosteres); amino acid extensions; and/or other chemical moieties such as, e.g., poly(ethylene glycol) and hydrophobic acids. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders such as, e.g., skeletal dysplasias and achondroplasia, and vascular smooth muscle disorders such as, e.g., restenosis and arteriosclerosis.