The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Jul. 27, 2011
Applicants:
Sergei Gryaznov, San Mateo, CA (US);
Ronald G. Schultz, Urbana, MO (US);
Inventors:
Sergei Gryaznov, San Mateo, CA (US);
Ronald G. Schultz, Urbana, MO (US);
Assignee:
Geron Corporation, Menlo Park, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); C12Q 1/68 (2006.01); C07G 3/00 (2006.01); C07H 21/02 (2006.01); C07H 21/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2'-arabino-fluoronucleoside and an internucleoside 3′-NH—P(═O)(OR)—O-5′ linkage, where R is a positively charged counter ion or hydrogen, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive phosphoramidate 2′-aribino-fluorooligonucleotides have a high RNA binding affinity to complementary nucleic acids and are base and acid stable.