The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 2013
Filed:
Jan. 14, 2010
Craig A. Smith, Seattle, WA (US);
Steven Wiley, Seattle, WA (US);
Ajamete Kaykas, Seattle, WA (US);
Peter Probst, Seattle, WA (US);
Craig A. Smith, Seattle, WA (US);
Steven Wiley, Seattle, WA (US);
Ajamete Kaykas, Seattle, WA (US);
Peter Probst, Seattle, WA (US);
The Board of Trustees of the Leland Standford Junior University, Palo Alto, CA (US);
Abstract
Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.