The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2013
Filed:
Apr. 24, 2012
Jae Yang Kong, Seoul, KR;
Woo-kyu Park, Cheongju, KR;
Heeyeong Cho, Daejeon, KR;
Daeyoung Jeong, Daejeon, KR;
Gildon Choi, Daejeon, KR;
Hun Yeong Koh, Seoul, KR;
Sang Hee Kim, Seoul, KR;
AE Nim Pae, Seoul, KR;
Yong Seo Cho, Seoul, KR;
Joo Hwan Cha, Seoul, KR;
Hyunah Choo, Seoul, KR;
Sang Eun Chae, Daejeon, KR;
Hee-yoon Lee, Daejeon, KR;
Jae Yang Kong, Seoul, KR;
Woo-Kyu Park, Cheongju, KR;
Heeyeong Cho, Daejeon, KR;
Daeyoung Jeong, Daejeon, KR;
Gildon Choi, Daejeon, KR;
Hun Yeong Koh, Seoul, KR;
Sang Hee Kim, Seoul, KR;
Ae Nim Pae, Seoul, KR;
Yong Seo Cho, Seoul, KR;
Joo Hwan Cha, Seoul, KR;
Hyunah Choo, Seoul, KR;
Sang Eun Chae, Daejeon, KR;
Hee-Yoon Lee, Daejeon, KR;
Korea Research Institute of Chemical Technology, Daejeon, KR;
Abstract
The present invention relates to a novel piperazinyl-propyl-pyrazole derivative, a method of its preparation and a pharmaceutically acceptable composition comprising the same. The novel piperazinyl-propyl-pyrazole derivative of the present invention has superior selective affinity for dopamine Dreceptor, can effectively inhibit psychotic behavior (cage climbing) induced by apomorphine, and has relatively low adverse effects in mouse rotarod test. Therefore, it can be developed as a therapeutic agent for the treatment and prevention of central nervous system (CNS) disorders, in particular, schizophrenia, attention deficit hyperactivity disorder, depression, stress diseases, panic disorder, phobia, obsessive-compulsive disorder, posttraumatic stress disorder, cognitive disorder, Alzheimer's disease, Parkinson's disease, anxiety, paraphrenia, mania, seizure disorder, personality disorder, migraine, drug addiction, alcohol addiction, obesity, eating disorder, and sleeping disorder.