The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2013
Filed:
Sep. 30, 2011
Marc Besman, Studio City, CA (US);
Erik Bjornson, Studio City, CA (US);
Feroz Jameel, Covina, CA (US);
Ramesh Kashi, Walnut, CA (US);
Michael Pikal, Mansfield Center, CT (US);
Serguei Tchessalov, Ashford, CT (US);
John Carpenter, Littleton, CO (US);
Marc Besman, Studio City, CA (US);
Erik Bjornson, Studio City, CA (US);
Feroz Jameel, Covina, CA (US);
Ramesh Kashi, Walnut, CA (US);
Michael Pikal, Mansfield Center, CT (US);
Serguei Tchessalov, Ashford, CT (US);
John Carpenter, Littleton, CO (US);
Baxter International Inc., Deerfield, IL (US);
University of Connecticut, Farmington, CT (US);
Abstract
An albumin-free Factor VIII formulation comprising: 4% to 10% of a bulking agent selected from the group consisting of mannitol, glycine and alanine; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. Alternatively, the formulation can comprise 2% to 6% hydroxyethyl starch; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; 100 mM to 300 mM NaCl; and a buffering agent. In a further embodiment, the formulation can comprise: 300 mM to 500 mM NaCl; 1% to 4% of a stabilizing agent selected from the group consisting of sucrose, trehalose, raffinose, and arginine; 1 mM to 5 mM calcium salt; and a buffering agent.