The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2013
Filed:
Jun. 12, 2001
Neil Cook, Dover, MA (US);
Albie Santos, Cardiff, GB;
Nigel Bosworth, Cardiff, GB;
Jan Wolber, Cardiff, GB;
Mike Looker, Cardiff, GB;
Peter Knox, Wokingham, GB;
Jan Jenrik Ardenkjaer-larsen, Malmo, SE;
Klaes Golman, Malmo, SE;
Neil Cook, Dover, MA (US);
Albie Santos, Cardiff, GB;
Nigel Bosworth, Cardiff, GB;
Jan Wolber, Cardiff, GB;
Mike Looker, Cardiff, GB;
Peter Knox, Wokingham, GB;
Jan Jenrik Ardenkjaer-Larsen, Malmo, SE;
Klaes Golman, Malmo, SE;
GE Healthcare Limited, Buckinghamshire, GB;
Abstract
The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.