The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 12, 2013
Filed:
Dec. 09, 2008
Applicants:
Robert A. Larossa, Chadds Ford, PA (US);
Dana R. Smulski, Wilmington, DE (US);
Vasantha Nagarajan, Wilmington, DE (US);
Inventors:
Robert A. Larossa, Chadds Ford, PA (US);
Dana R. Smulski, Wilmington, DE (US);
Vasantha Nagarajan, Wilmington, DE (US);
Assignee:
Butamax(TM) Advanced Biofuels LLC, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 1/21 (2006.01); C12P 7/26 (2006.01); C12P 7/16 (2006.01);
U.S. Cl.
CPC ...
Abstract
Using screening of transposon random insertion mutants, genes involved in accumulation of (p)ppGpp were found to be involved in bacterial cell response to butanol. Reduced production of proteins with enzymatic activity for (p)ppGpp biosynthesis confers increased butanol tolerance. Bacterial strains with reduced (p)ppGpp accumulation and having a butanol or 2-butanone biosynthetic pathway are useful for production of butanol or 2-butanone.