The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 05, 2013
Filed:
May. 02, 2012
Jonathan K. Stiles, Powder Spings, GA (US);
James W. Lillard, Smyrna, GA (US);
Henry B. Armatei Armah, Mount Pleasant, MI (US);
Nana Otoo Wilson, Atlanta, GA (US);
Jonathan K. Stiles, Powder Spings, GA (US);
James W. Lillard, Smyrna, GA (US);
Henry B. Armatei Armah, Mount Pleasant, MI (US);
Nana Otoo Wilson, Atlanta, GA (US);
Morehouse School of Medicine, Atlanta, GA (US);
Abstract
Biomarkers for predicting the severity of malaria and methods for their detection are disclosed. In one aspect, the present application discloses CXCL4, CXCL10, VEGF, PGDF, IL-1Ra, IL-8, MIP-1β, sFas, Fas-L, sTNF-R2, and sTNF-R1 as biomarkers for the severity of malaria. In another aspect, the present application discloses a method for determining the severity of malaria and predicting mortality due to cerebral malaria. The method comprises the detection of the biomarkers CXCL4 and/or CXCL10 and at least one more biomarker and determining the severity of malaria and predicting mortality due to cerebral malaria based upon the ratio of expression of the biomarkers in the subject versus the expression of the biomarkers in a control.